Camptothecin

Cat. No. 1100

Camptothecin C20H16N2O4 [7689-03-4]

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Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Biological Activity

Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Technical Data

M.Wt:
348.36
Formula:
C20H16N2O4
Solubility:
Soluble to 5 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
7689-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863. PMID: 8449612.

Liu (1989) DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 58 351. PMID: 2549853.

Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 260 14873. PMID: 2997227.

Merck Index 12 1783.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Camptothecin include:

Neveu et al (2016) CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia. Haematologica. PMID: 27540136.

Gründemann et al (2013) Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One 8 e68016. PMID: 23840803.

Hellinger et al (2013) Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol 151 299. PMID: 24216163.

Lamy et al (2013) Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. PLoS One 8 e70846. PMID: 23936472.

Ma et al (2005) Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. Sci Rep 280 16208. PMID: 15687501.

Do you know of a great paper that uses Camptothecin from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Camptothecin, supplier, DNA, topoisomerases, inhibitors, inhibits, Isomerases, chemotherapeutics, Tocris Bioscience, DNA Topoisomerase Inhibitor products

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