Ketoconazole

Cat. No. 1103

Ketoconazole C26H28Cl2N4O4 [65277-42-1]

Price and Availability

For Ketoconazole pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine

Biological Activity

Antifungal agent; potent inhibitor of cytochrome P450c17.

Technical Data

M.Wt:
531.44
Formula:
C26H28Cl2N4O4
Solubility:
Soluble to 50 mM in ethanol and to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
65277-42-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727. PMID: 9694927.

Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371. PMID: 1472102.

Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515. PMID: 2724954.

Merck Index 12 5313.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Ketoconazole from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Ketoconazole, supplier, Cytochrome, P450c17, inhibitors, inhibits, CYP, Tocris Bioscience, Cytochrome P450 Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

New Products in this Area

Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

pCPA methyl ester hydrochloride

Tryptophan hydroxylase inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2