Ketoconazole

Cat. No. 1103

Ketoconazole C26H28Cl2N4O4 [65277-42-1]

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Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine

Biological Activity

Antifungal agent; potent inhibitor of cytochrome P450c17.

Technical Data

M.Wt:
531.44
Formula:
C26H28Cl2N4O4
Solubility:
Soluble to 50 mM in ethanol and to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
65277-42-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727. PMID: 9694927.

Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371. PMID: 1472102.

Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515. PMID: 2724954.

Merck Index 12 5313.

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Keywords: Ketoconazole, supplier, Cytochrome, P450c17, inhibitors, inhibits, CYP, Tocris Bioscience, Cytochrome P450 Inhibitor products

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