Cat. No. 1103
Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichloro
Biological ActivityAntifungal agent; potent inhibitor of cytochrome P450c17.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727. PMID: 9694927.
Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371. PMID: 1472102.
Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515. PMID: 2724954.
Merck Index 12 5313.
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Citations are publications that use Tocris products.
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Keywords: Ketoconazole, supplier, Cytochrome, P450c17, inhibitors, inhibits, CYP, Tocris Bioscience, Cytochrome P450 Inhibitor products
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