Zopiclone

Cat. No. 1094

Zopiclone C17H17ClN6O3 [43200-80-2]

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Chemical Name: 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester

Biological Activity

A non benzodiazepine BZR agonist, with little difference in affinity for the BZ1 and BZ2 subtypes; however its CNS effects differ from those of other BZR ligands and this may be due to interaction with a different subunit.

Technical Data

M.Wt:
388.81
Formula:
C17H17ClN6O3
Solubility:
Soluble to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
43200-80-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Munakata et al (1996) Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones. Br.J.Pharmacol. 118 820. PMID: 8762113.

Im et al (1993) Potentiation of γ-aminobutyric acid induced chloride currents by various benzodiazepine site agonists with the α1γ2, β2γ2 and α1β2γ2 subtypes of cloned γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 866. PMID: 7901754.

Goa and Heel (1986) Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as a hypnotic. Drugs 32 48. PMID: 2874974.

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Keywords: Zopiclone, supplier, Benzodiazepine, agonists, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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