LY 311727

Cat. No. 3627

LY 311727 C22H27N2O5P [164083-84-5]

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Chemical Name: [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonic acid

Biological Activity

Selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 values are <1 μM for group IIA and <50 μM for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 μM.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
>97 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bernatchez et al (2001) VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. Br.J.Pharmacol. 134 197. PMID: 11522612.

Bridonneau et al (1997) High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A2 (hnps-PLA2). J.Med.Chem 41 778.

Schevitz et al (1995) Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat.Struct.Biol. 2 429. PMID: 7664101.

If you know of a relevant reference for LY 311727 please let us know.

Citations are publications that use Tocris products. Selected citations for LY 311727 include:

Mock et al (2013) Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2 responsive liposome in prostate cancer. Integr Biol (Camb) 5 172. PMID: 22890797.

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Keywords: LY 311727, supplier, LY311727, secreted, phospholipases, a2, sPLA2, PLA2, inhibitors, inhibits, Tocris Bioscience, Phospholipase Inhibitor products

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