Cat. No. 1092
Biological ActivityPotent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).
(Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH2-NH), Lys-13 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Okawa et al (1999) Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 127 123. PMID: 10369464.
Guerrini et al (1998) A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 123 163. PMID: 9489602.
Xu et al (1998) [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 249 127. PMID: 9682833.
Guerrini et al (1997) Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 40 1789. PMID: 9191955.
If you know of a relevant reference for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 please let us know.
Citations are publications that use Tocris products. Selected citations for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 include:
McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. J Biol Chem 132 1175. PMID: 11250866.
Do you know of a great paper that uses [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 from Tocris? If so please let us know.
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Keywords: [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, supplier, Selective, nociceptin, agonists, Receptors, ORL1, OP4, NOP, Opioid, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, Tocris Bioscience, NOP Receptor Agonist products