Vincristine sulfate

Cat. No. 1257

Vincristine sulfate C46H56N4O10.H2SO4 [2068-78-2]

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Chemical Name: 22-Oxovincaleukoblastine

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data

M.Wt:
923.04
Formula:
C46H56N4O10.H2SO4
Solubility:
Soluble to 100 mM in water
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
2068-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Wang et al (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 44 355. PMID: 10501907.

Takano et al (1993) Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 189 197. PMID: 8321748.

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Vincristine sulfate include:

Goldman et al (2015) Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun 6 6139. PMID: 25669750.

Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840. PMID: 25493630.

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Keywords: Vincristine sulfate, supplier, Disrupts, microtubules, Tau, Tubulin, Mitosis, chemotherapeutics, Tocris Bioscience, Microtubule products

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