Cat. No. 1257
Chemical Name: 22-Oxovincaleukoblastine
Biological ActivityAnticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 44 355. PMID: 10501907.
Takano et al (1993) Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 189 197. PMID: 8321748.
Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.
If you know of a relevant reference for Vincristine sulfate please let us know.
Citations are publications that use Tocris products. Selected citations for Vincristine sulfate include:
Goldman et al (2015) Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun 6 6139. PMID: 25669750.
Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840. PMID: 25493630.
Heinemann et al (2011) Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer. Sci Rep 11 221. PMID: 21645351.
Do you know of a great paper that uses Vincristine sulfate from Tocris? If so please let us know.
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Keywords: Vincristine sulfate, supplier, Disrupts, microtubules, Tau, Tubulin, Mitosis, chemotherapeutics, Tocris Bioscience, Microtubule products