Vinblastine sulfate

Cat. No. 1256

Vinblastine sulfate C46H58N4O9.H2SO4 [143-67-9]

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Chemical Name: Vincaleukoblastine

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Technical Data

M.Wt:
909.06
Formula:
C46H58N4O9.H2SO4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>95 %
Storage:
Desiccate at +4°C
CAS No:
143-67-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Veldhoen et al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736. PMID: 22430212.

Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131. PMID: 9813016.

Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918. PMID: 8362985.

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Vinblastine sulfate include:

Musiwaro et al (2013) Characteristics and requirements of basal autophagy in HEK 293 cells. BMC Cancer 9 1407. PMID: 23800949.

Ahmad et al (2010) Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells. Trop Life Sci Res 21 101. PMID: 24575203.

Do you know of a great paper that uses Vinblastine sulfate from Tocris? If so please let us know.

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Keywords: Vinblastine sulfate, supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, chemotherapeutics, Tocris Bioscience, Microtubule products

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