Cat. No. 3619
Alternative Name: Homotaurine
Chemical Name: 3-Amino-1-propanesulfonic acid
Biological ActivitySulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gervais et al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537. PMID: 16675063.
Santa-Maria et al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 2 17.
Fariello et al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241. PMID: 7199633.
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Keywords: Tramiprosate, supplier, Sulfated, glycosaminoglycan, sGAG, Targets, soluble, Amyloid-beta, β-Amyloid, beta-Amyloid, b-amyloid, decrease, amyloid, plaque, deposition, Precursor, Protein, APP, Secretase, beta, Peptides, GABAA, GABAC, GABAB, Receptors, analogue, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products
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