Cat. No. 3619

Tramiprosate C3H9NO3S [3687-18-1]

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Alternative Name: Homotaurine

Chemical Name: 3-Amino-1-propanesulfonic acid

Biological Activity

Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

Technical Data

Soluble to 100 mM in water
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gervais et al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537. PMID: 16675063.

Santa-Maria et al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 2 17.

Fariello et al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241. PMID: 7199633.

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Citations are publications that use Tocris products.

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Keywords: Tramiprosate, supplier, Sulfated, glycosaminoglycan, sGAG, Targets, soluble, Amyloid-beta, β-Amyloid, beta-Amyloid, b-amyloid, decrease, amyloid, plaque, deposition, Precursor, Protein, APP, Secretase, beta, Peptides, GABAA, GABAC, GABAB, Receptors, analogue, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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