Cat. No. 3618
Alternative Name: Calcium acetylhomotaurinate
Chemical Name: 3-(Acetylamino)-1-propanesulfonic acid hemicalcium salt
Biological ActivityGABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Popp and Lovinger (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur.J.Pharmacol. 394 221. PMID: 10771287.
Berton et al (1998) Acamprosate enhances N-methyl-D-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin.Exp.Res. 22 183. PMID: 9514305.
Spanagel et al (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur.J.Pharmacol. 305 39. PMID: 8813529.
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Keywords: Acamprosate calcium, supplier, GABA, agonists, receptors, glutamate, modulators, metabotropic, mGlu, mGluR, ionotropic, systems, glutamatergics, Tocris Bioscience, GABAA Receptor Agonist products
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