Acamprosate calcium

Cat. No. 3618

Acamprosate calcium C5H10NO4S.½Ca [77337-73-6]

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Alternative Name: Calcium acetylhomotaurinate

Chemical Name: 3-(Acetylamino)-1-propanesulfonic acid hemicalcium salt

Biological Activity

GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.

Technical Data

C5H10NO4S.½ Ca
Soluble to 100 mM in water
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Popp and Lovinger (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur.J.Pharmacol. 394 221. PMID: 10771287.

Berton et al (1998) Acamprosate enhances N-methyl-D-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons. Alcohol Clin.Exp.Res. 22 183. PMID: 9514305.

Spanagel et al (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur.J.Pharmacol. 305 39. PMID: 8813529.

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Keywords: Acamprosate calcium, supplier, GABA, agonists, receptors, glutamate, modulators, metabotropic, mGlu, mGluR, ionotropic, systems, glutamatergics, Tocris Bioscience, GABAA Receptor Agonist products

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