SDZ SER 082 fumarate
Cat. No. 1255
Chemical Name: (+)-cis-4,5,7a,8,9,10,11,11a-Octahy
Biological ActivitySelective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kalkman et al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201. PMID: 9570468.
Mora et al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051. PMID: 9408213.
Nozulak et al (1995) (+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity. J.Med.Chem. 38 28. PMID: 7837236.
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Keywords: SDZ SER 082 fumarate, supplier, Selective, 5-HT2B/2C, antagonists, Serotonin, Receptors, SDZSER, fumarate082, SDZSER082, Tocris Bioscience, 5-HT2B Receptor Antagonist products