SDZ SER 082 fumarate

Cat. No. 1255

SDZ SER 082 fumarate C15H20N2.C4H4O4 [1417343-80-6]

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Chemical Name: (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine fumarate

Biological Activity

Selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M.Wt:
344.41
Formula:
C15H20N2.C4H4O4
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
1417343-80-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kalkman et al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201. PMID: 9570468.

Mora et al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051. PMID: 9408213.

Nozulak et al (1995) (+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity. J.Med.Chem. 38 28. PMID: 7837236.

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