SANT-2

Cat. No. 3617

SANT-2 C26H26ClN3O4 [329196-48-7]

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Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

Biological Activity

Inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).

Technical Data

M.Wt:
479.96
Formula:
C26H26ClN3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
329196-48-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Rominger et al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995. PMID: 19304771.

Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci. 99 14071.

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Keywords: SANT-2, supplier, inhibitors, inhibits, Hedgehog, Hh, signaling, signalling, antagonizes, antagonises, smoothened, smo, receptors, antagonist, Tocris Bioscience, Hedgehog Signaling Inhibitor products

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