Cat. No. 3617
Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlor
Biological ActivityInhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Rominger et al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995. PMID: 19304771.
Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci. 99 14071.
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Citations are publications that use Tocris products.
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Keywords: SANT-2, supplier, inhibitors, inhibits, Hedgehog, Hh, signaling, signalling, antagonizes, antagonises, smoothened, smo, receptors, antagonist, Tocris Bioscience, Hedgehog Signaling Inhibitor products