Cat. No. 3617
Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlor
Biological ActivityInhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Rominger et al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995. PMID: 19304771.
Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci. 99 14071.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SANT-2 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SANT-2, supplier, inhibitors, inhibits, Hedgehog, Hh, signaling, signalling, antagonizes, antagonises, smoothened, smo, receptors, antagonist, Tocris Bioscience, Hedgehog Signaling Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity caveolin-1 ligandSAG 21k
Hedgehog signaling activator; brain penetrant and orally bioavailableG10
Activator of STING-dependent signaling
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.