Cat. No. 3616
Chemical Name: (2R,6aS,12aS)-1,2,12,12a-Tetrahydro
Biological ActivityMitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mader et al (2012) Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chem.Neurosci. 3 1063. PMID: 23259041.
Gomez et al (2007) Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front.Biosci. 12 1079. PMID: 17127363.
Cherednichenko et al (2004) NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ.Res. 94 478. PMID: 14699012.
Uversky (2004) Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res. 318 225. PMID: 15258850.
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Citations are publications that use Tocris products. Selected citations for Rotenone include:
Juliana et al (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. Leukemia 287 36617. PMID: 22948162.
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Keywords: Rotenone, supplier, inhibitors, inhibits, complex, I, mitochondrial, electron, transport, chain, Oxidative, phosphorylation, parkinson's, parkinsons, parkinsonism, complex, I, Tocris Bioscience, Oxidative Phosphorylation Inhibitor products
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