Cat. No. 1043
Chemical Name: 2-[(2,6-Dimethylphenyl)amino]-N,N,N
Biological ActivitySodium channel blocker.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cuevas and Adams (1994) Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. Br.J.Pharmacol. 11 663. PMID: 7517326.
Hanck et al (1994) Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J.Gen.Physiol. 103 19. PMID: 8169596.
If you know of a relevant reference for QX 222 please let us know.
Citations are publications that use Tocris products. Selected citations for QX 222 include:
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388. PMID: 15616319.
Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707. PMID: 11159438.
Do you know of a great paper that uses QX 222 from Tocris? If so please let us know.
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Keywords: QX 222, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX222, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products