Novokinin

Cat. No. 3615

Novokinin Arg-Pro-Leu-Lys-Pro-Trp

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Biological Activity

Angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4. Orally active.

Technical Data

M.Wt:
795.98
Formula:
C39H61N11O7
Sequence:
RPLKPW
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
358738-77-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ohinata et al (2009) Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice. Peptides 30 1105. PMID: 19463743.

Yamada et al (2008) A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci.Biotechnol.Biochem. 72 257. PMID: 18175894.

Yamada et al (2008) Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor. Peptides 29 412. PMID: 18207609.

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Keywords: Novokinin, supplier, Orally, active, agonists, Angiotensin, Receptors, AT2, Tocris Bioscience, Angiotensin AT2 Receptor Agonist products

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