Cat. No. 1034

4-P-PDOT C19H21NO [620170-78-7]

Price and Availability

For 4-P-PDOT pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: AH 024

Chemical Name: cis-4-Phenyl-2-propionamidotetralin

Biological Activity

Melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365. PMID: 9089668.

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4-P-PDOT include:

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298. PMID: 24574803.

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127. PMID: 20959363.

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478. PMID: 20696141.

Danilova et al (2004) Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. J Pharmacol Exp Ther 18 751. PMID: 14766799.

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J 108 625. PMID: 11518737.

Do you know of a great paper that uses 4-P-PDOT from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: 4-P-PDOT, supplier, MT2, antagonists, Receptors, Melatonin, AH024, Tocris Bioscience, Melatonin Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

New Products in this Area

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist


FFA2 antagonist/inverse agonist

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist


SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist


Selective positive allosteric modulator at GPR68

BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

Montelukast sodium

CysLT1 and GPR17 antagonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.