NBQX disodium salt

Cat. No. 1044

NBQX disodium salt C12H6N4O6SNa2 [479347-86-9]

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Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo. More water soluble disodium salt of NBQX (Cat. No. 0373). Also available as part of the AMPA Receptor Tocriset™.

Licensing Information

Sold with the permission of Novo Nordisk A/S

Technical Data

Soluble to 100 mM in water
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36. PMID: 8199874.

Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 146. PMID: 7504337.

Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35. PMID: 1504814.

Zeman and Lodg (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367. PMID: 1382781.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for NBQX disodium salt include:

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Neurochem Int 10 e0131430. PMID: 26102354.

Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Sci Rep 35 5680. PMID: 25855181.

Malvaez et al (2015) Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. PLoS One 5 12511. PMID: 26212790.

Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Neuron 18. PMID: 25522418.

Bortone et al (2014) Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex. J Neurosci 82 474. PMID: 24656931.

Crook et al (2014) A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina. Vis Neurosci 31 57. PMID: 24801624.

Reinhard et al (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One 9 e106148. PMID: 25165854.

Bloodgood et al (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121. PMID: 24201284.

He et al (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition. Int J Neuropsychopharmacol 109 1535. PMID: 23255721.

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320. PMID: 23008234.

Gensel et al (2012) Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. J Neurosci 7 e33519. PMID: 22428066.

Olsen et al (2012) Gain control by layer six in cortical circuits of vision. J Neurophysiol 483 47. PMID: 22367547.

Zheng et al (2010) SAP102 is a highly mobile MAGUK in spines. J Neurosci 30 4757. PMID: 20357126.

Shin et al (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab 26 1018. PMID: 16340958.

Harkany et al (2004) Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. PLoS One 24 4978. PMID: 15163690.

Liu et al (2004) Astrocyte-mediated activation of neuronal kainate receptors. Nature 101 3172. PMID: 14766987.

Do you know of a great paper that uses NBQX disodium salt from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: NBQX disodium salt, supplier, water, soluble, NBQX, Glutamate, AMPA, Receptors, iGlu, Ionotropic, antagonists, Tocris Bioscience, AMPA Receptor Antagonist products

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