Cat. No. 3607
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4
Biological ActivitySelective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943. PMID: 19271755.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SU 3327 include:
Lo et al (2014) TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin 35 339. PMID: 24487964.
Do you know of a great paper that uses SU 3327 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: SU 3327, supplier, SU3327, JNK, kinases, inhibitors, inhibits, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated, Tocris Bioscience, JNK/c-Jun Inhibitor products
Find multiple products by catalog number
New Products in this Area
Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylationBIRB 796
High affinity and selective p38 kinase inhibitorPH 797804
Potent and selective p38α/β inhibitorDEL 22379
ERK dimerization inhibitor
October 30 - November 3, 2016
Boston, MA, USA