Cat. No. 3607
Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4
Biological ActivitySelective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943. PMID: 19271755.
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Citations are publications that use Tocris products. Selected citations for SU 3327 include:
Lo et al (2014) TNF-α induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin 35 339. PMID: 24487964.
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Keywords: SU 3327, supplier, SU3327, JNK, kinases, inhibitors, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated, Tocris Bioscience, JNK/c-Jun Inhibitor products
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