(R)-CR8

Cat. No. 3605

(R)-CR8 C24H29N7O.3HCl [294646-77-8]

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Chemical Name: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine trihydrochloride

Biological Activity

Inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 130, 130 and 600 nM for cdk1/cyclin B, cdk5/p35 (cdk5/p25) and CK1, respectively).

Technical Data

M.Wt:
540.92
Formula:
C24H29N7O.3HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
294646-77-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Oumata et al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51 5229. PMID: 18698753.

If you know of a relevant reference for (R)-CR8 please let us know.

Citations are publications that use Tocris products. Selected citations for (R)-CR8 include:

Malonia et al (2015) F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Microvasc Res 112 8632. PMID: 26124108.

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046. PMID: 24740004.

Wu et al (2014) Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways. J Neurosci 34 10989. PMID: 25122899.

Wu et al (2013) TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways. J Neurosci 33 12447. PMID: 23884949.

Wu et al (2013) Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion. Neurotherapeutics 10 520. PMID: 23775067.

Wu et al (2012) Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion. J Neuroinflammation 9 169. PMID: 22784881.

Do you know of a great paper that uses (R)-CR8 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (R)-CR8, supplier, cdk1, cdk5, inhibitors, inhibits, CK1, cyclin-dependent, kinases, casein, kinase, 1, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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