QX 314 bromide
Cat. No. 1014
Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethy
Biological ActivityMembrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Talbot and Sayer (1996) Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J.Neurophysiol. 76 2120. PMID: 8890325.
Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 73 911. PMID: 7760149.
Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain.Res. 639 320. PMID: 8205485.
Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37. PMID: 4541340.
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Citations are publications that use Tocris products. Selected citations for QX 314 bromide include:
McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171. PMID: 26658868.
Sametsky et al (2015) Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus. J Neurosci 35 9369. PMID: 26109660.
Xue et al (2015) Structural elements that underlie Doc2β function during asynchronous synaptic transmission. Proc Natl Acad Sci U S A 112 E4316. PMID: 26195798.
Dale et al (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol 28 891. PMID: 25122043.
Gaffaney et al (2014) Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission. Mol Biol Cell 25 481. PMID: 24356452.
Toyoda et al (2009) Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain 5 46. PMID: 19664265.
Hong et al (2008) Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice. J Neurosci 28 13003. PMID: 19036993.
Baldelli et al (2007) Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses. J Neurosci 27 13520. PMID: 18057210.
Xu et al (2006) Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain 2 29. PMID: 16948848.
Sur et al (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A 100 13674. PMID: 14595031.
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Keywords: QX 314 bromide, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, bromide, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
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