Cat. No. 3603
Alternative Name: Kempferol
Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl
Biological ActivityNaturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kang et al (2009) Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 611 17. PMID: 19356725.
Suh et al (2009) Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull. 32 746. PMID: 19336918.
Vay et al (2009) Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation. J.Physiol. 580 39.
Cho et al (2007) Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res. 67 8104. PMID: 17804722.
Montero et al (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 384 19. PMID: 15324303.
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Citations are publications that use Tocris products. Selected citations for Kaempferol include:
Tran et al (2014) Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9 2796. PMID: 25279668.
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Keywords: Kaempferol, supplier, Mitochondrial, Ca2+, uniporter, MCU, activators, proapoptotic, downregulates, PLK1, expression, Ion, Pumps, Transporters, Apoptosis, Inducer, Tocris Bioscience, Apoptosis Inducing products