Cat. No. 1035
Chemical Name: 8-Methoxy-2-propionamidotetralin
Biological ActivityMelatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.
Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365. PMID: 9089668.
Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.
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Keywords: 8-M-PDOT, supplier, Melatonin, agonists, Receptors, MT, 8MPDOT, Tocris Bioscience, Melatonin Receptor Agonist products
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