RS 56812 hydrochloride

Cat. No. 0988

RS 56812 hydrochloride C18H21N3O2.HCl [143339-12-2]

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Chemical Name: (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride

Biological Activity

A highly potent and selective 5-HT3 partial agonist, with a pKi at 5-HT3 receptors in rat brain of 9.6, and greater than 1000-fold selectivity over a wide range of other neurotransmitter receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M.Wt:
347.84
Formula:
C18H21N3O2.HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
143339-12-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Clark et al (1995) N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg.Med.Chem.Lett. 5 1853.

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Citations are publications that use Tocris products. Selected citations for RS 56812 hydrochloride include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Mol Psychiatry 7 2336. PMID: 26114334.

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Keywords: RS 56812 hydrochloride, supplier, 5-HT3, partial, agonists, Serotonin, Receptors, RS56812, hydrochloride, Tocris Bioscience, 5-HT3 Receptor Agonist products

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Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

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