RS 67333 hydrochloride
Cat. No. 0989
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl
Biological ActivityA potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo, with an intrinsic activity relative to 5-HT of 0.5.
Licensing InformationSold with the permission of Roche Bioscience
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36 689. PMID: 9225295.
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387. PMID: 8564196.
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391. PMID: 8578609.
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Citations are publications that use Tocris products. Selected citations for RS 67333 hydrochloride include:
Eriksson et al (2013) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Learn Mem 18 1096. PMID: 23032875.
Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453. PMID: 19649285.
Warner-Schmidt et al (2009) Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci 29 1937. PMID: 19211900.
Huang and Kandel (2007) Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. J Neurosci 14 497. PMID: 17626908.
Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. Obesity (Silver Spring) 27 3111. PMID: 17376972.
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Keywords: RS 67333 hydrochloride, supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67333, hydrochloride, Tocris Bioscience, 5-HT4 Receptor Agonist products
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