RS 67506 hydrochloride
Cat. No. 0990
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl
Biological ActivityA potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
Licensing InformationSold with the permission of Roche Bioscience
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Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689. PMID: 9225295.
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387. PMID: 8564196.
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391. PMID: 8578609.
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Citations are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:
Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7. PMID: 20085655.
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Keywords: RS 67506 hydrochloride, supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, Tocris Bioscience, 5-HT4 Receptor Agonist products