RS 67506 hydrochloride

Cat. No. 0990

RS 67506 hydrochloride C18H28ClN3O4S.HCl [168986-61-6]

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Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride

Biological Activity

A potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M.Wt:
454.41
Formula:
C18H28ClN3O4S.HCl
Solubility:
Soluble to 80 mM in water
Storage:
Store at RT
CAS No:
168986-61-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689. PMID: 9225295.

Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387. PMID: 8564196.

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391. PMID: 8578609.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7. PMID: 20085655.

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Keywords: RS 67506 hydrochloride, supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, Tocris Bioscience, 5-HT4 Receptor Agonist products

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