W146

Cat. No. 3602

W146 C16H27N2O4P [909725-61-7]

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Alternative Name: ML 056

Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

Biological Activity

Potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.

Technical Data

M.Wt:
342.37
Formula:
C16H27N2O4P
Solubility:
Soluble to 20 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
909725-61-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308. PMID: 18708635.

Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434. PMID: 16829954.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for W146 include:

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184. PMID: 26419927.

Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Mol Cell Biol 16 29454. PMID: 26690412.

Beckham et al (2013) Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Oncogenesis 2 e49. PMID: 23732709.

Beckham et al (2013) Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PLoS One 8 e76593. PMID: 24098536.

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Keywords: W146, supplier, potent, selective, sphingosine-1-phosphate, s1p1, antagonists, sphingolipids, ML056, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Antagonist products

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