CYM 5442 hydrochloride

Cat. No. 3601

CYM 5442 hydrochloride C23H27N3O4.HCl [1094042-01-9]

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Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol hydrochloride

Biological Activity

Potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.

Technical Data

M.Wt:
445.94
Formula:
C23H27N3O4.HCl
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1094042-01-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 74 1308. PMID: 18708635.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:

Li et al (2015) Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation 12 70. PMID: 25880547.

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Keywords: CYM 5442 hydrochloride, supplier, sphingosine-1-phosphate, S1P1, receptors, agonists, CYM5442, hydrochloride, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products

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