CYM 5442 hydrochloride
Cat. No. 3601
Chemical Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-
Biological ActivityPotent and selective S1P1 agonist in vitro (EC50 = 1.35 nM). Activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Mol.Pharmacol. 74 1308. PMID: 18708635.
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Citations are publications that use Tocris products. Selected citations for CYM 5442 hydrochloride include:
Li et al (2015) Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation 12 70. PMID: 25880547.
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Keywords: CYM 5442 hydrochloride, supplier, sphingosine-1-phosphate, S1P1, receptors, agonists, CYM5442, hydrochloride, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Agonist products
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