CP 93129 dihydrochloride

Cat. No. 1032

CP 93129 dihydrochloride C12H13N3O.2HCl [879089-64-2]

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Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride

Biological Activity

Potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
288.18
Formula:
C12H13N3O.2HCl
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
879089-64-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260. PMID: 24381287 .

Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304. PMID: 9566817.

Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241.

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Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex 3 e00103. PMID: 25692021.

Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron 19 1915. PMID: 19056862.

Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther 51 239. PMID: 16846858.

Rau et al (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med 318 676. PMID: 16687477.

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Keywords: CP 93129 dihydrochloride, supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, Tocris Bioscience, 5-HT1B Receptor Agonist products

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