CP 93129 dihydrochloride
Cat. No. 1032
Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4
Biological ActivityPotent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260. PMID: 24381287 .
Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304. PMID: 9566817.
Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241.
If you know of a relevant reference for CP 93129 dihydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79. PMID: 28300552.
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex 3 e00103. PMID: 25692021.
Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron 19 1915. PMID: 19056862.
View Related Products by Product Action
Keywords: CP 93129 dihydrochloride, supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, Tocris Bioscience, 5-HT1B Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent 5-HT1A partial agonist and SSRI; antidepressant
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.