Cat. No. 3600
Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzi
Biological ActivityPotent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Su et al (2009) 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol.Pharmcol. 75 43.
Monovich et al (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorg.Med.Chem.Lett. 17 2310. PMID: 17317170.
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Citations are publications that use Tocris products. Selected citations for FIPI include:
Bonnefond et al (2015) Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Int J Mol Sci 20 535. PMID: 25627260.
Do you know of a great paper that uses FIPI from Tocris? If so please let us know.
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Keywords: FIPI, supplier, potent, phospholipases, D, PLD1, PLD2, inhibitors, inhibits, esterases, Tocris Bioscience, Phospholipase Inhibitor products