Cat. No. 3596
Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydrox
Biological ActivityOrally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559. PMID: 19359799.
Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669. PMID: 19208898.
Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S. PMID: 1728846.
If you know of a relevant reference for Voglibose please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Voglibose from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Voglibose, supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, Tocris Bioscience, Glycosylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and highly selective PDE5 inhibitor; orally bioavailable7-Ethoxyresorufin
Fluorometric CYP450 substrateGaleterone
CYP17 inhibitor; also androgen receptor antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.