Cat. No. 3596
Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydrox
Biological ActivityOrally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559. PMID: 19359799.
Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669. PMID: 19208898.
Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S. PMID: 1728846.
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Keywords: Voglibose, supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, Tocris Bioscience, Glycosylase Inhibitor products
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