Cat. No. 1003
Chemical Name: 3-[[4-(4-Chlorophenyl)-4-hydroxypip
Biological ActivityA potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.
Licensing InformationSold with the permission of Merck Sharp and Dohme Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Millan et al (2000) S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J.Pharmacol.Exp.Ther. 293 1063. PMID: 10869411.
Pillai et al (1998) Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively. Neuropharmacology 37 983. PMID: 9833627.
Bowery et al (1996) Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626. Br.J.Pharmacol. 119 1491. PMID: 8968560.
Kulagowski et al (1996) 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J.Med.Chem. 39 1941. PMID: 8642550.
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Citations are publications that use Tocris products. Selected citations for L-741,626 include:
Newton et al (2016) Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D 2 and D 3 Receptors PLoS One 11 e0158808. PMID: 27379794.
Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. J Neurosci 11 2057. PMID: 26649942.
Belinsky et al (2013) Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev 22 1522. PMID: 23286225.
Billes et al (2012) Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab 1 86. PMID: 24024122.
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Keywords: L-741,626, supplier, High, affinity, D2, antagonists, Dopamine, Receptors, dopaminergic, L741742, Tocris Bioscience, D2 Receptor Antagonist products