Cat. No. 3595
Alternative Name: Tosedostat
Chemical Name: α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydrox
Biological ActivityAminopeptidase inhibitor (IC50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4 hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Moore et al (2009) Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 8 762. PMID: 19372548.
Krige et al (2008) CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 68 6669. PMID: 18701491.
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Citations are publications that use Tocris products.
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Keywords: CHR 2797, supplier, aminopeptidases, inhibitors, inhibits, proteases, proteinases, CHR2797, Tocris Bioscience, Aminopeptidase Inhibitor products