Anandamide (in Tocrisolve™ 100)

Cat. No. 1017

Anandamide (in Tocrisolve 100) C22H37NO2 [94421-68-8]

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Alternative Names: Arachidonylethanolamide, AEA

Chemical Name: N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Biological Activity

Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Ki values are 89 and 371 nM for CB1 and CB2 receptors respectively; EC50 values are 18, 31 and 27 nM at GPR55, CB1 and CB2 respectively; pKi = 5.68 for rVR1. Also blocks TNF-α-induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol (Anandamine, Cat. No. 1339). Tocrisolve Control (Cat. No. 1684) also available.

Technical Data

M.Wt:
347.54
Formula:
C22H37NO2
Storage:
Store at +4°C
CAS No:
94421-68-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.

Sancho et al (2003) Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 63 429. PMID: 12527815.

Gardiner et al (2002) Complex regional haemodynamic effects of anandamide in conscious rats. Br.J.Pharmacol. 135 1889. PMID: 11959791.

Kagaya et al (2002) Characterization of the anandamide-induced depolarization of guinea-pig isolated vagus nerve. Br.J.Pharmacol. 137 39. PMID: 12183329.

Ross et al (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 132 631. PMID: 11159715.

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635. PMID: 10469884.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Anandamide (in Tocrisolve™ 100) include:

Mair et al (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. Br J Pharmacol 161 176. PMID: 20718749.

Ho and Gardiner (2009) Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. Cereb Cortex 156 94. PMID: 19133994.

Ho et al (2008) 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol 155 837. PMID: 18695637.

Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. Cell Death Differ 26 9666. PMID: 16988037.

Movsesyan et al (2004) Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Br J Pharmacol 11 1121. PMID: 15375383.

Do you know of a great paper that uses Anandamide (in Tocrisolve™ 100) from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Anandamide (in Tocrisolve 100), supplier, Endogenous, CB, agonist, water-soluble, emulsion, vanilloid, Cannabinoids, Non-Selective, Receptors, Vanillioid, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, cb2r, cb1r, Tocris Bioscience, Non-selective Cannabinoid Agonist products

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