Cat. No. 3594
Biological ActivityGRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dang et al (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322. PMID: 19279269.
Macrez et al (1997) A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J.Biol.Chem. 272 23180. PMID: 9287322.
Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J.Biol.Chem. 269 6193. PMID: 8119963.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for GRK2i include:
Stott et al (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Apoptosis 112 6497. PMID: 25941381.
Do you know of a great paper that uses GRK2i from Tocris? If so please let us know.
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Keywords: GRK2i, supplier, GRK, inhibitory, polypeptide, Gbg, antagonists, Gβγ, Gbetagamma, G, protein, heterotrimeric, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products
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