Goserelin acetate

Cat. No. 3592

Goserelin acetate Pyr-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NH-NH-CO-NH2

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Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers.

Technical Data


(Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2)

Soluble in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chatzaki et al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059. PMID: 8616851.

Dondi et al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091. PMID: 8033142.

Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2 254.

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Keywords: Goserelin acetate, supplier, GnRH, receptor, antagonists, Receptors, gonadotropin, Gonadotrophin-Releasing, Hormone, ICI118630, chemotherapeutics, Tocris Bioscience, Gonadotropin-Releasing Hormone Receptor Agonist products

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