LY 235959

Cat. No. 1019

LY 235959 C11H20NO5P [137433-06-8]

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Chemical Name: [3S-(3α,4aα,6β,8aα)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid)

Biological Activity

Competitive NMDA receptor antagonist.

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data

M.Wt:
277.26
Formula:
C11H20NO5P
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at +4°C
CAS No:
137433-06-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Borowicz et al (1996) Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia 37 618. PMID: 8681893.

Ellison (1994) Competitive and non-competitive NMDA antagonists induce similar limbic degeneration. Neuroreport 5 2688. PMID: 7696633.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for LY 235959 include:

Fowler et al (2011) Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature 471 597. PMID: 21278726.

Kenny et al (2009) NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology 34 266. PMID: 18418357.

Do you know of a great paper that uses LY 235959 from Tocris? If so please let us know.

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Keywords: LY 235959, supplier, Competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, LY235959, Tocris Bioscience, NMDA Receptor Antagonist products

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