Fluoxetine hydrochloride

Cat. No. 0927

Fluoxetine hydrochloride C17H18F3NO.HCl [56296-78-7]

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Chemical Name: N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride

Biological Activity

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data

M.Wt:
345.78
Formula:
C17H18F3NO.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
56296-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Chang et al (2010) Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 54 707. PMID: 19598107.

Beck et al (1997) Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 281 115. PMID: 9103487.

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.

Benfield et al (1986) Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 32 481. PMID: 2878798.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Fluoxetine hydrochloride include:

Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366. PMID: 25762681.

Silva et al (2014) Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion. PLoS One 9 e89641. PMID: 24586928.

MacLean et al (2004) Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. J Pharmacol Exp Ther 109 2150. PMID: 15078799.

Do you know of a great paper that uses Fluoxetine hydrochloride from Tocris? If so please let us know.

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Keywords: Fluoxetine hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products

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