Fluvoxamine maleate

Cat. No. 1033

Fluvoxamine maleate C15H21F3N2O2.C4H4O4 [61718-82-9]

Price and Availability

For Fluvoxamine maleate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate

Biological Activity

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.

Technical Data

M.Wt:
434.41
Formula:
C15H21F3N2O2.C4H4O4
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
61718-82-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.

Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117. PMID: 8831113.

Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313. PMID: 3096686.

Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505. PMID: 302726.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:

Su et al (2014) Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. PLoS One 7 435. PMID: 24396420.

Agarwal et al (2013) TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. World J Gastroenterol 8 e63028. PMID: 23667566.

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808. PMID: 21957243.

O'Donnell et al (2010) The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One 5. PMID: 20957046.

Hirano et al (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 144 695. PMID: 15678084.

Do you know of a great paper that uses Fluvoxamine maleate from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Fluvoxamine maleate, supplier, High, affinity, σ1, sigma1, ligands, 5-HT, reuptake, inhibitors, inhibits, Receptors, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

5-HT Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

divider line

New Products in this Area

Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.