Fluvoxamine maleate

Cat. No. 1033

Fluvoxamine maleate C15H21F3N2O2.C4H4O4 [61718-82-9]

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Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate

Biological Activity

Selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.

Technical Data

M.Wt:
434.41
Formula:
C15H21F3N2O2.C4H4O4
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
61718-82-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.

Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117. PMID: 8831113.

Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313. PMID: 3096686.

Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505. PMID: 302726.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:

Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808. PMID: 21957243.

O'Donnell et al (2010) The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One 5. PMID: 20957046.

Hirano et al (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 144 695. PMID: 15678084.

Do you know of a great paper that uses Fluvoxamine maleate from Tocris? If so please let us know.

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Keywords: Fluvoxamine maleate, supplier, High, affinity, σ1, sigma1, ligands, 5-HT, reuptake, inhibitors, inhibits, Receptors, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products

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