Cat. No. 1033
Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl
Biological ActivitySelective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.
Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117. PMID: 8831113.
Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313. PMID: 3096686.
Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505. PMID: 302726.
If you know of a relevant reference for Fluvoxamine maleate please let us know.
Citations are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:
Su et al (2014) Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. PLoS One 7 435. PMID: 24396420.
Agarwal et al (2013) TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. World J Gastroenterol 8 e63028. PMID: 23667566.
Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808. PMID: 21957243.
O'Donnell et al (2010) The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One 5. PMID: 20957046.
Hirano et al (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 144 695. PMID: 15678084.
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Keywords: Fluvoxamine maleate, supplier, High, affinity, σ1, sigma1, ligands, 5-HT, reuptake, inhibitors, inhibits, Receptors, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products
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