Cat. No. 3586
Alternative Name: GR 43175
Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl
Biological Activity5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ottani et al (2004) Effect of sumatriptan in different models of pain in rats. Eur.J.Pharmacol. 497 181. PMID: 15306203.
Peroutka (1990) Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 554. PMID: 2177047.
Peroutka and McCarthy (1989) Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 163 133. PMID: 2545459.
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Keywords: Sumatriptan succinate, supplier, 5-HT1, receptor, agonists, Non-Selective, Serotonin, Receptors, GR43175, Tocris Bioscience, 5-HT1D Receptor Agonist products
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April 10 - 13, 2017