Sumatriptan succinate

Cat. No. 3586

Sumatriptan succinate C14H21N3O2S.C4H6O4 [103628-48-4]

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Alternative Name: GR 43175

Chemical Name: 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate

Biological Activity

5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent.

Technical Data

Soluble to 100 mM in water and to 75 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ottani et al (2004) Effect of sumatriptan in different models of pain in rats. Eur.J.Pharmacol. 497 181. PMID: 15306203.

Peroutka (1990) Sumatriptan in acute migraine: pharmacology and review of world experience. Headache 30 554. PMID: 2177047.

Peroutka and McCarthy (1989) Sumatriptan (GR 43175) interacts selectivity with 5-HT1B and 5-HT1D binding sites. Eur.J.Pharmacol. 163 133. PMID: 2545459.

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Citations are publications that use Tocris products.

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Keywords: Sumatriptan succinate, supplier, 5-HT1, receptor, agonists, Non-Selective, Serotonin, Receptors, GR43175, Tocris Bioscience, 5-HT1D Receptor Agonist products

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