C 021 dihydrochloride
Cat. No. 3581
Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cyclohep
Biological ActivityPotent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64. PMID: 19081254.
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Citations are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:
McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121. PMID: 25012628.
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