C 021 dihydrochloride

Cat. No. 3581

C 021 dihydrochloride C27H41N5O2.2HCl [864289-85-0]

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Chemical Name: 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride

Biological Activity

Potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).

Technical Data

M.Wt:
540.57
Formula:
C27H41N5O2.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
864289-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64. PMID: 19081254.

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Citations are publications that use Tocris products. Selected citations for C 021 dihydrochloride include:

McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121. PMID: 25012628.

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Keywords: C 021 dihydrochloride, supplier, C021, dihydrochloride, potent, CCR4, chemokines, receptors, antagonists, Tocris Bioscience, Chemokine CC Receptor Antagonist products

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