5-BDBD

Cat. No. 3579

5-BDBD C17H11BrN2O2 [768404-03-1]

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Chemical Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one

Biological Activity

Potent P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM).

Technical Data

M.Wt:
355.19
Formula:
C17H11BrN2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
768404-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Casati et al (2011) Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP. Cell Death Differ. 18 396. PMID: 20798687.

Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409. PMID: 18042830.

If you know of a relevant reference for 5-BDBD please let us know.

Citations are publications that use Tocris products. Selected citations for 5-BDBD include:

Chen et al (2016) Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice. Mol Med Rep 13 697. PMID: 26648454.

Kawano et al (2015) Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS One 10 e0127919. PMID: 26030257.

Mascanfroni et al (2015) Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Circulation 21 638. PMID: 26005855.

Maslieieva and Thompson (2014) A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus. Channels (Austin) 8 131. PMID: 24418937.

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050. PMID: 24048730.

Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Nat Med 305 F396. PMID: 23720349.

Vergani et al (2013) Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. J Biol Chem 127 463. PMID: 23250993.

Nörenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48. PMID: 22506590.

Trabanelli et al (2012) Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol 189 1303. PMID: 22753942.

Wu et al (2011) Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol 301 H69. PMID: 21460192.

Do you know of a great paper that uses 5-BDBD from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 5-BDBD, supplier, potent, P2X4, antagonists, purinergic, receptors, BDBD, Tocris Bioscience, Purinergic (P2X) Receptor Antagonist products

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