Buspirone hydrochloride

Cat. No. 0962

Buspirone hydrochloride C21H31N5O2.HCl [33386-08-2]

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Chemical Name: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride

Biological Activity

Classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.

Technical Data

M.Wt:
421.97
Formula:
C21H31N5O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
33386-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gobert et al (1999) Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie its action. Neuroscience 93 1251. PMID: 10501449.

Cao and Rodgers (1997) Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology 36 1089. PMID: 9294974.

Goa and Ward (1986) Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 32 114. PMID: 2874976.

Merck Index 12 1528.

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Citations are publications that use Tocris products. Selected citations for Buspirone hydrochloride include:

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7. PMID: 20085655.

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Keywords: Buspirone hydrochloride, supplier, 5-HT1A, partial, agonists, Serotonin, Receptors, Tocris Bioscience, 5-HT1A Receptor Agonist products

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