Cat. No. 3576

()-5'-Chloro-5'-deoxy-ENBA C17H22ClN5O3 [103626-26-2]

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Chemical Name: N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine

Biological Activity

Highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). Reverses formaline-induced nocifensive behavior in mice; antinociceptive.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Franchetti et al (2009) N6-cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. J.Med.Chem. 52 2393. PMID: 19317449.

Trivedi et al (1989) N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. J.Med.Chem. 32 8. PMID: 2909748.

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Keywords: ()-5'-Chloro-5'-deoxy-ENBA, supplier, highly, selective, A1, adenosines, receptors, agonists, ()-5-Chloro-5-deoxy-ENBA, ENBA, Tocris Bioscience, A1 Receptor Agonist products

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