Cat. No. 3575
Chemical Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-
Biological ActivityPotent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lewis et al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916. PMID: 19268584.
Scott et al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108. PMID: 19136975.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for VU 0155069 include:
Sulzmaier et al (2012) PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31 3547. PMID: 22105357.
Do you know of a great paper that uses VU 0155069 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 0155069, supplier, VU0155069, PLD1, phospholipases, D, specific, inhibitors, inhibits, potent, selective, esterases, Tocris Bioscience, Phospholipase Inhibitor products
Find multiple products by catalog number
March 18 - 22, 2017
Little Rock, ARK, USA