RuBi-Glutamate

Cat. No. 3574

RuBi-Glutamate C28H32N5O4PRu.2NaPF6

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Chemical Name: (bis(2,2'-Bipyridine-N,N')trimethylphosphine)-(S)-1-aminopropane-1,3-dicarboxylic acid ruthenium(2+) complex sodium hexafluorophosphate salt

Biological Activity

Ruthenium-bipyridine-trimethylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Has high quantum efficiency and can be used at low concentrations, partly avoiding blockade of GABAergic transmission seen with other caged glutamate compounds. Displays high spatial resolution and generates excitatory responses in individual dendritic spines with physiological kinetics.

Licensing Information

Sold under licence from Columbia University

Technical Data

M.Wt:
970.54
Formula:
C28H32N5O4PRu.2NaPF6
Solubility:
Soluble to 20 mM in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Salierno et al (2010) A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes. J.Inorg.Biochem. 104 418. PMID: 20060592.

Fino et al (2009) RuBi-Glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines. Front.Neural Circuits 3 1. PMID: 19506708.

If you know of a relevant reference for RuBi-Glutamate please let us know.

Citations are publications that use Tocris products. Selected citations for RuBi-Glutamate include:

Blaesse et al (2015) μ-Opioid Receptor-Mediated Inhibition of Intercalated Neurons and Effect on Synaptic Transmission to the Central Amygdala. Neuroscience 35 7317. PMID: 25972162.

Do you know of a great paper that uses RuBi-Glutamate from Tocris? If so please let us know.

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Keywords: RuBi-Glutamate, supplier, Caged, Glutamate, mGluR, iGluR, Receptors, agonists, ionotropic, metabotropic, Tocris Bioscience, Photolysis products

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