LFM-A13

Cat. No. 1300

LFM-A13 C11H8Br2N2O2 [62004-35-7]

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Chemical Name: 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

Biological Activity

Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μM.

Technical Data

M.Wt:
360
Formula:
C11H8Br2N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
62004-35-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Crosby and Pool (2002) Interaction of Bruton's tyrosine kinase and protein kinase Cθ in platelets. J.Biol.Chem. 277 9958. PMID: 11788586.

Mahajan et al (1999) Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]. J.Biol.Chem. 274 9587. PMID: 10092645.

Vassilev et al (1999) Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J.Biol.Chem. 274 1646. PMID: 9880544.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for LFM-A13 include:

Hart et al (2011) Essential role of Stat3 in PI3K-induced oncogenic transformation. Pain 108 13247. PMID: 21788516.

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Keywords: LFM-A13, supplier, Potent, selective, BTK, inhibitors, inhibits, Brutons, Tyrosine, Kinases, LFMA13, Tocris Bioscience, Bruton's Tyrosine Kinase Inhibitor products

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