Cat. No. 3571
Chemical Name: 2-Bromo-N-[4-chloro-3-[[(3R)-1-meth
Biological ActivitySelective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM).
Licensing InformationSold with the permission of GlaxoSmithKline
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Behm et al (2008) Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br.J.Pharmacol. 155 374. PMID: 18587423.
Douglas et al (2005) Nonpeptide urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br.J.Pharmacol. 145 620. PMID: 15852036.
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Keywords: SB 657510, supplier, SB657510, UT-II, urotensin-II, receptors, antagonists, GlaxoSmithKline, Tocris Bioscience, Urotensin-II Receptor Antagonist products
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