(S)-WAY 100135 dihydrochloride

Cat. No. 1253

(S)-WAY 100135 dihydrochloride C24H33N3O2.2HCl [149007-54-5]

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Chemical Name: (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride

Biological Activity

Potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM). Centrally active on systemic administration.

Licensing Information

Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814

Technical Data

M.Wt:
468.47
Formula:
C24H33N3O2.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming and to 10 mM in water with sonication
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
149007-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Rodgers and Cole (1994) Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 261 321. PMID: 7813555.

Cliffe et al (1993) (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J.Med.Chem. 36 1509. PMID: 8496920.

Fletcher et al (1993) WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur.J.Pharmacol. 237 283. PMID: 8365456.

Fletcher et al (1993) Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 14 41. PMID: 8122313.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (S)-WAY 100135 dihydrochloride include:

Borroto-Escuela et al (2012) The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. J Neurosci 32 6295. PMID: 22553035.

Grace et al (2012) 5-HT1A receptor-responsive pedunculopontine tegmental neurons suppress REM sleep and respiratory motor activity. J Neurosci 32 1622. PMID: 22302804.

Do you know of a great paper that uses (S)-WAY 100135 dihydrochloride from Tocris? If so please let us know.

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