Cat. No. 1251
Chemical Name: (S)-α-Amino-2',4'-dichloro-4-hydroxy-5
Biological ActivityPotent competitive antagonist at the NMDA receptor (pKi = 8.5). Selective over a range of other receptor sites.
Licensing InformationSold with the permission of Novartis Pharma AG
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro. Neuropharmacology 35 643. PMID: 8887974.
Urwyler et al (1996) Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo. Neuropharmacology 35 655. PMID: 8887975.
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Keywords: SDZ 220-040, supplier, Potent, competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZ220-040, Tocris Bioscience, NMDA Receptor Antagonist products