Cat. No. 3568
Alternative Name: Ro 16-6028
Chemical Name: (13aS)-8-Bromo-11,12,13,13a-tetrahy
Biological ActivityPartial agonist at the GABAA benzodiazepine site (EC50 = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Munro et al (2008) Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain. J.Pharmacol.Exp.Ther. 327 969. PMID: 18791060.
Rundfeldt et al (1995) Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 275 693. PMID: 7473156.
Puia et al (1992) Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology 89 3620.
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Keywords: Bretazenil, supplier, benzodiazepines, partial, agonists, GABAA, receptors, Ro16-6028, Tocris Bioscience, GABAA Receptor Benzodiazepine products