L189

Cat. No. 3561

L189 C11H10N4OS [64232-83-3]

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Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

Biological Activity

DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Technical Data

M.Wt:
246.29
Formula:
C11H10N4OS
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
64232-83-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169. PMID: 18451142.

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Keywords: L189, supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, Tocris Bioscience, DNA Ligase Inhibitor products

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