Cat. No. 3561
Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethy
Biological ActivityDNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169. PMID: 18451142.
If you know of a relevant reference for L189 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses L189 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: L189, supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, Tocris Bioscience, DNA Ligase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Cereblon ubiquitination inhibitor; also TNFα inhibitor and antiangiogenicLenalidomide
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligasecis VH 298
Negative control for VH 298VH 298
High-affinity inhibitor of VHLcis MZ 1
Negative Control for MZ1MZ 1
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.